International Journal of Biological & Pharmaceutical Science

ROLE OF GENETIC ALTERATIONS IN BREAST CANCER PROGRESSION.

Tandralee Bhuyan — 2025-05-15

Breast cancer is a multifactorial disease and represents the tumor formation through non-controlled cellular proliferation in the breast tissue. To understand the concept of breast cancer, one has to study the types, risk factors, diagnosis, treatment and latest research about the disease[1].While breast cancer remains a premier health concern, the advances made in research methods and tools, early detection and treatments have dramatically improved survival rates and quality of life for many patients [2].The incidence rates for breast cancer have been on the increase due to increased awareness, better diagnostic facilities and changes in lifestyle[3].The Wnt signaling pathway normally plays a very fundamental role in cell growth, differentiation and embryonic development. Understanding this pathway is important for the development of targeted therapies and advanced understanding in the advancement of regenerative medicine[4].HCCRI is an abbreviation of Human Cervical cancer Related 1, a gene implicated in the development of cancer especially in cervical cancer. It encodes for a protein involved in regulating all proliferation and apoptosis. Overexpression of HCCRI has been implicated in tumor progressions and prognosis in various cancers. Research indicates that HCCRI could be utilized as a biomarker for diagnosis in cancer and prognosis while the targeting of HCCRI can offer new therapeutic strategies in managing cancer[5].The TIMP2 gene encodes a tissue inhibitor of metalloproteinases 2-a protein that plays a critical role in regulating extracellular matrix remodeling through the inhibition of matrix metalloproteinases. This inhibition controls the degradation and remodeling of tissue leading to various physiological processes such as wound healing and embryogenesis. TIMP2 is involved in maintaining tissue integrity and has been implicated in various pathological conditions including cancer metastasis and cardiovascular diseases. It operates by binding to MMPs, thus preventing their activity and subsequent breakdown of extracellular characterized by excessive tissue remodelling or insufficient tissue repair[6].

OUTCOMES OF SOY PROTEIN CONSUMPTION ON THE BIOCHEMICAL PARAMETERS OF PLASMA IN HUMAN VOLUNTEERS - POSTMENOPAUSAL WOMEN

Dr.A.Helah Kiranmai — 2025-03-13

In the recent decade the pre and post menopausal complications and symptoms are increasing alarmingly posing a multidisciplinary intervention. Various chronic & temporary diseases in postmenopausal women are caused by rapid changes in hormones and stressful conditions and are accompanied by rapid changes in body composition (muscle, bone, and fat). In order to maintain a healthy body composition and overall well being the post menopausal women in the ageing society are ingesting high quality protein foods these days. Literature is proving the beneficial effects of soy protein in post menopausal women as soy proteins are rich in isoflavones. Nutrigenomics and personalized nutrition are taking big seat in treating the subjects. But there is is limited /no public data available on the consumption of soy protein – and its impact on various plasma parameters. In conjunction with this, the present study was aimed at the impact of various types of soy proteins on the plasma parameters of female human volunteers aged 45± 7 years mean age being 45 years for a period of 12 weeks. The present study is showing hypoglycemic effect and has impact on lipid profile with less significant changes on proteins, but much intensive research has to be done to establish the results

PHYTOCHEMICAL ANALYSIS OF MEDICINAL PLANTS WITH ANTIBACTERIAL PROPERTIES

Dr. Salam Himika Devi — 2025-04-25

The worldwide increase of antibiotic-resistant bacterial strains requires immediate development of alternative antimicrobial medicines. Medical plants possess therapeutic properties because of their bioactive phytochemicals which demonstrate antimicrobial action. Secondary metabolites produced by plants including alkaloids and flavonoids and tannins and saponins and terpenoids demonstrate inhibitory properties against different harmful microorganisms. The analysis of antibacterial medicinal plants in this study evaluates their potential to combat Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli bacterial infections. The conventional qualitative and quantitative techniques were used for phytochemical screening to detect important secondary metabolites. Scientists utilized the disc diffusion method to measure inhibition zone widths for evaluating antibacterial activities of these plant extracts. They conducted the minimum inhibitory concentration (MIC) assay to find the lowest effective concentration which halted bacterial growth. Plants containing elevated levels of alkaloids together with phenolic chemicals and flavonoids demonstrated the strongest antibacterial properties. Two of the selected plants demonstrated significant inhibitory properties against S. aureus and E. coli through their active compounds in Ocimum sanctum (holy basil) and Curcuma longa (turmeric).

These findings demonstrate the potential of medicinal plants strong in phytochemicals as a viable natural antibacterial agent source. These bioactive substances work by disrupting bacterial membranes, inhibiting enzymes, and interfering with the creation of proteins. These plant-derived chemicals may be utilized as supplemental or alternative antimicrobial agents to treat bacterial infections, especially those brought on by drug-resistant strains, due to their natural origin and broad-spectrum activity. In order to create plant-based antibacterial medicines, more study on the separation, purification, and structural characterisation of these phytochemicals as well as their therapeutic uses would be essential.

A PREVALENCE STUDY ON THE OCCURRENCE OF WORK ACCIDENTS AMONG THE MANUAL MATERIAL HANDLING WORKERS OF THE CENTRAL MARKET AREA IN AGARTALA CITY, WEST TRIPURA

Swagatam Das — 2025-02-19

One of the most important central market areas of Agartala city is the Maharajganj Bazaar (Gol Bazar) where material handling, loading, and unloading work is a continuous process. Manual material handling (MMH), being a strenuous work often leads to injuries, accidents, and even death. Fifty MMH workers of the central market area in Agartala city were selected to identify the risk factors contributing to accidents. A standardized modified Nordic questionnaire was performed. Analysis of working postures by OWAS method was done and history of accident cases was collected. It was revealed that most accidents, being struck by objects and slipping and falling, have occurred during lifting and carrying loads. Accident records suggested that few accident cases have reached the hospitals indicating a general negligence of attending the hospitals.