IN-SITU OPHTHALMIC GELS: A SMART APPROACH TO OCULAR DRUG DELIVERY — A REVIEW
DOI:
https://doi.org/10.53555/eijbps.v11i1.62Keywords:
in situ gel, ocular drug administration, nano particle laden insitu gelling approachAbstract
The eye is the body's most delicate organ. Because of the eye's complex anatomy, small absorptive surface, low transparency of the cornea, lipophilicity of the corneal epithelium, pre-corneal loss (from nasolacrimal drainage), bonding of the drug with proteins in tear fluid, blinking, low conjunctival sac capacity, and ultimately poor ocular therapy, designing an ocular drug delivery system is the most difficult task for pharmaceutical scientists. This overview discusses the polymers utilised, research advancements in the field, and the in situ gelling mechanism, which turns liquid formulations into gels under specific physiological or environmental conditions. In situ ocular gels for drug delivery go through this change when they come into touch with the ocular surface. Various processes, contingent on the gel's composition and intended characteristics, are responsible for this transformation. In situ gelling enhances drug retention, bioavailability, and contact time by causing the liquid formulation to solidify into a gel upon contact with ocular tissues.
Common methods of in situ ocular gel formation include temperature-, pH-, and ion-induced gelation. These gels offer a versatile and efficient platform while resolving a number of issues with the present ocular therapeutic administration methods.
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