TAMARIND PULP CATALYSED SYNTHESIS OF N, 7-BIS (SUBSTITUTED PHENYL)-4,7 DIHYDRO-5 ISOPROPYL [1,2,4] TRIAZOLO [1,5-A] PYRIMIDINE-6-CARBOXAMIDE DERIVATIVES AS ANTIMICROBIAL AGENTS
DOI:
https://doi.org/10.53555/2xqp0e37Keywords:
3-amino-1,2,4 triazole, N-(substituted p-chlorophenyl)-4-methyl-3-oxo-pentanamide, termarind juice, antibacterial, antifungalAbstract
[1,2,4] triazolo [1,5-a] pyrimidine skeletons are widely used to design many antimicrobial agents. Therefore the synthesis of N-7 bis (substituted pheny) 4,7-dihydro-5-isopropyl –[1,2,4-triazolo-[1,5-a] pyrimidine-6-carboxamide (Pc-1 to Pc-10) was accomplished from 3-amino-1,2,4 triazole, N-(substituted p-chlorophenyl) 4-methyl-3-oxo. pentanamide and aldehydes in domestic micro woven for 10min. Synthesized aromatic compounds (Pc 1 to Pc10) were characterized by elemental analyses, M.P., I.R. and 1HNMR spectroscopic studies. All newly synthesized compounds were assessed for their antibacterial and antifungal activity.
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